• Users Online: 204
  • Home
  • Print this page
  • Email this page
Home Current issue Archives Ahead of print Search Subscribe Instructions Submit article About us Editorial board Contacts Login 
ORIGINAL ARTICLE
Year : 2013  |  Volume : 34  |  Issue : 1  |  Page : 61-68

Impact of a diet rich in n-3 fatty acids on Alzheimer's disease


1 Institute of Psychiatry, Faculty of Medicine, Ain Shams University, Cairo, Egypt
2 Outpatient Medical Laboratory, Cairo, Egypt
3 Department of Community Medicine, National Nutrition Institute, Cairo, Egypt
4 Department of Public Health and Preventive Medicine, BeniSueif University, BeniSueif, Egypt

Correspondence Address:
Abeer M. Eissa
MD, Institute of Psychiatry,WHO Collaborating Center for Training and Research, Ain Shams University, Abbasia, Cairo
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.7123/01.EJP.0000422813.73592.b3

Rights and Permissions

Background

Alzheimer’s disease (AD) is a progressive neurodegenerative disease. The potential effect of nutrition on development of AD has become a topic of increasing scientific and public interest. High intakes of saturated and trans-unsaturated (hydrogenated) fats were positively associated with increased risk for AD, whereas intakes of polyunsaturated and monounsaturated fats were protective against cognitive decline in the elderly. Would foods rich in these fatty acids delay cognitive decline in elderly people who are vulnerable to AD?

Objectives

The aim of this study was to measure the concentration of plasma fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) in patients with AD and study the relationship between foods rich in these fatty acids and severity of cognitive decline.

Methods

A total of 62 individuals were screened for cognitive decline using the mini-mental status examination test and were diagnosed with AD using the Diagnostic and Statistical Manual of Mental Disorders, 4th ed., diagnostic criteria. Data on nutrition were obtained and blood samples were withdrawn to determine the plasma levels of the fatty acids EPA and DHA.

Results

Patients with late-onset AD have significantly higher intake of food and food supplements containing both fatty acids.

Conclusion

High intake of food and food supplements rich in EPA and DHA fatty acids may delay the onset of AD.



[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed968    
    Printed77    
    Emailed0    
    PDF Downloaded104    
    Comments [Add]    
    Cited by others 1    

Recommend this journal