|Year : 2016 | Volume
| Issue : 3 | Page : 118-124
Functional outcome in childhood-onset schizophrenia in Nigeria: a 3-year longitudinal study
Musa U Umar MBBS, FWACP , Shehu Sale
Department of Psychiatry, Child and Adolescent Mental Health Unit, Aminu Kano Teaching Hospital, Bayero University, Kano, Nigeria
|Date of Submission||11-Feb-2016|
|Date of Acceptance||01-May-2016|
|Date of Web Publication||13-Dec-2016|
Musa U Umar
Department of Psychiatry, Child and Adolescent Mental Health Unit, Aminu Kano Teaching Hospital, Bayero University, Zaria Road, PMB 3452, 77189 UNIBAYERO NG, Kano
Source of Support: None, Conflict of Interest: None
Background The outcome of childhood-onset schizophrenia (COS) is generally regarded as poor. Few prospective studies have been reported from developing countries.
Aim The aim of the present study was to assess the functional outcome in COS and the factors associated with poor outcome.
Methods This 3-year prospective study included 19 patients with COS. Diagnosis was based on the Diagnostic and Statistical Manual of Mental Disorders, 4th ed., criteria using the Kiddie-Schedule for Affective Disorders and Schizophrenia − Present and Lifetime Version; severity was assessed through the Positive and Negative Symptoms Scale, whereas the measure of outcome used was Children’s Global Assessment Scale.
Results The mean duration of follow-up was 39.53 (SD ±5.37) months. The mean age of onset of COS was 10.47 (SD ±0.91) years. At the end of the study, 31.6% of the participants had good outcome, 42.1% had moderate outcome, and 26.3% had poor outcome. Factors associated with poor outcome included history of perinatal complication, more negative symptoms, and longer duration of untreated psychosis.
Conclusion More than a third of the sample showed good outcome over the few years of follow-up. On the basis of the findings of this study, we recommend an early intervention.
Keywords: childhood-onset schizophrenia, functional outcome, prospective follow-up study
|How to cite this article:|
Umar MU, Sale S. Functional outcome in childhood-onset schizophrenia in Nigeria: a 3-year longitudinal study. Egypt J Psychiatr 2016;37:118-24
|How to cite this URL:|
Umar MU, Sale S. Functional outcome in childhood-onset schizophrenia in Nigeria: a 3-year longitudinal study. Egypt J Psychiatr [serial online] 2016 [cited 2019 Jan 16];37:118-24. Available from: http://new.ejpsy.eg.net/text.asp?2016/37/3/118/195549
| Introduction|| |
Schizophrenia most commonly emerges during late teens and early adulthood, but it can also be diagnosed during childhood (American Psychiatric Association, 2013). Childhood-onset schizophrenia (COS) is a severe form of psychotic disorder that occurs at the age of 13 years or younger and is often chronic and persistently debilitating (Remschmidt et al., 2007). It is a severe form of the late adolescent and early adult-onset disorder (Rapoport and Inoff-Germain, 2000).
COS is a rare disorder; in preadolescents, the estimated prevalence is less than one case per 10 000 (Asarnow et al., 2004). The number of new cases significantly increase during late adolescence, reaching an approximate prevalence of 1% for later-onset schizophrenia. It occurs more in males unlike the adult-onset type that has equal ratio.
Individuals with COS present with more premorbid impairment than do those with late-onset, with an increased prevalence of genetic abnormalities (Addington and Rapoport, 2009). A clinical and outcome study by Hassan and Taha (2011) reported that about 24% of patients with early-onset schizophrenia had good outcome, and that premorbid adjustment, intelligence quotient, negative symptoms, and gradual onset were associated with poor outcome. In a recent systematic review, good outcome for early-onset schizophrenia was 15.4%, with male sex and longer follow-up periods as predictors of poor outcome (Clemmensen et al., 2012). Most studies around the world have reported poor prognosis for COS (Jarbin and von Knorring, 2003; Gonthier and Lyon, 2004; Röpcke and Eggers, 2005; Remschmidt et al., 2007), although a recent meta-analysis reported better outcome in patients with early-onset schizophrenia compared with the adult-onset group (Amminger et al., 2011).
Because COS is a rare disorder, it is poorly understood and has not received adequate attention from researchers (Bartlett, 2004; Clemmensen et al., 2012). It is important that clinicians have a better understanding of the manifestation and prognosis of COS to better recognize and treat it (Taylor, 1998). Few studies on COS have been reported in sub-Saharan Africa, mainly from South Africa (Maydell et al., 2009; Paruk et al., 2009). Both manual and electronic searches did not yield studies on COS in Nigeria. This study, therefore, serves as a template for further work in this area, especially prospectively following patients with COS into late adolescent and early adulthood. In this preliminary work, we report the outcome in terms of functioning of children with COS after 3 years of follow-up in Aminu Kano Teaching Hospital, Nigeria.
| Methods|| |
Design and setting
This was a prospective, longitudinal study of children with schizophrenia in the Child and Adolescent Mental Health Unit of Department of Psychiatry, Aminu Kano Teaching Hospital, Kano, Nigeria.
The study population included 19 patients among the 28 patients that were followed up for schizophrenia. Among the 28 patients, four patients had a change of diagnosis later, whereas five did not complete the study; thus, the dropout rate was 16.7%. All patients had been followed over a period of 3 years, with a mean of 39.53 (SD ±5.37), in a naturalistic pattern with full-structured clinical interviews. The follow-up involved a clinician-administered interview questionnaire to assess the progress of psychopathology, side effect of medications, and return to normal functioning. As COS is a rare disorder, the sample of 19 patients studied was largely adequate, which followed other studies around the world with samples ranging from 9 to 81 (Clemmensen et al., 2012). Those included in the study met the Diagnostic and Statistical Manual of Mental Disorders, 4th ed. (American Psychiatric Association, 1994) criteria for schizophrenia, and had the onset of illness before the age of 13 years. Patients with primary diagnosis of intellectual disability were excluded from the study.
Sociodemographic Record and Clinical Profile Questionnaire: The sociodemographic record included were age, sex, educational level of parents, family history of mental illness, and age of parents at birth of the patients. The clinical profile included history of associated risk factors like obstetric complications during birth of the patient, delayed developmental milestone, history of head injury, family history of diabetes mellitus, etc.
Kiddie-Schedule for Affective Disorder and Schizophrenia − Present and Lifetime Version (K-SADS-PL)
The K-SADS-PL is a semistructured instrument used in the diagnosis of childhood and adolescent mental illnesses. Depending on the severity of key current and past symptoms reported in the screening interview, any five diagnostic supplements (affective disorders, psychotic disorders, and others) can be administered. The interrater agreement of the instrument in scoring screens and diagnoses was high, with a range of 98–100% (Kaufman et al., 1996). The K-SADS-PL has been used extensively in the studies on psychiatric disorders in the child and adolescent age groups in several countries, including Nigeria (Adewuya et al., 2007; Shahrivar et al., 2010; Umar et al., 2015).
Brief Psychiatric Rating Scale for Children (BPRS-C)
The BPRS-C (Overall and Pfefferbaum, 1982) is a 21-item clinician-based rating scale designed for use in evaluating psychiatric problems of children and adolescents. It focuses on problems as rated by the clinicians to provide a descriptive profile of symptoms applicable to a broad range of child and adolescent psychiatric disorders as a compliment for clinician ratings of functional impairment. It is used as an outcome measure in research, managed care, and public sector child/adolescent clinical settings. Ratings are based on a seven-point scale: not present, very mild, mild, moderate, moderately severe, severe, and extremely severe. The interrater reliability of item ratings of the scale ranged from 0.46 to 0.89, while Cronbach’s α’s ranged from 0.69 to 0.91 for the seven subscales of BPRS-C.
Positive and Negative Symptoms Scale (PANSS)
The PANSS is a standardized instrument for the assessment of two distinct symptoms of schizophrenia − positive and negative symptoms (Kay et al., 1987). The scale has 30 items that are rated on a seven-point symptoms score. The ratings provide summary scores on seven-item positive scale, seven-item negative scale, 16-item general psychopathology scale, and a composite (positive minus negative) index.
Children’s Global Assessment Scale (CGAS)
CGAS is a numeric scale (1–100) designed to provide a global measure of level of functioning in children and adolescents (Shafer et al., 1983). This assessment scale (CGAS) was used to assess the social, educational, and psychological functioning of the adolescents, with a score of less than or equal to 70 indicating functional impairment. Individuals were rated as having good functioning when they scored greater than 70, moderate functioning when they scored between 40 and 70, and poor functioning when they scored less than 40. The CGAS has been used in children and adolescent in Nigeria (Bakare et al., 2011; Tunde-Ayinmode et al., 2012).
The study was approved by the Ethics Committee of Aminu Kano Teaching Hospital, Kano, Nigeria. Parents or guardians gave written informed consent before enrolling their children into the research. This was a prospective follow-up study of 19 patients with COS who were followed up using structured instruments for 3 years. To standardize the diagnosis of psychiatric disorder in suspected cases of schizophrenia, apart from clinical interview, structured clinical assessment with various instruments where carried out for children and adolescents consulting the Child and Adolescent Mental Health Unit of Aminu Kano Teaching Hospital, Kano, Nigeria. On each clinic visit, sets of instruments were used for further evaluation and assessment of diagnosis, functioning and improvement in clinical features during the course of the follow-ups, and side effects from medication. For patients with schizophrenia, the K-SADS-PL was used to confirm the clinical impression at 2–4 weeks from the first visit. The level of global dysfunction was assessed using the CGAS during the first visit and after every 6 months. The BPRS-C and PANSS were used to assess the severity of symptoms of schizophrenia at the start of the clinic visit.
Data analysis was done using the Statistical Package for Social Sciences (SPSS) Version 16 (Released 2007. SPSS for Windows, Version 16.0. Chicago, USA, SPSS Inc). The frequencies and cross tabulations of variables were done to check for data entry errors and missing values. The sociodemographic and clinical correlates were determined using descriptive statistical tools like means, SDs, and frequency tables. The relationship and significance between COS and clinical variables, and CGAS at 3 years and clinical variables were tested using the χ2-test with the Yates correction and t-test wherever appropriate. The level of significance was set at 0.05 (two-tailed). Logistic regression was carried out for variables found to be significantly associated with poor outcome.
| Results|| |
Demographic and premorbid characteristics of the patients
The clinic had 24 patients with COS during this period but only 19 completed the study. There were nine (47.4%) males and 10 (52.6%) females. Nearly half (47.4%) of them were first born. More than half of the total number of parents of the patients had tertiary education ([Table 1]). There was family history of mental illness in 57.9% of the participants. Eight (42.1%) patients had a history of perinatal complications and delayed developmental milestone ([Table 1]). The history of head trauma was recorded in five (26.3%) patients ([Table 1]).
The mean age of patients was 14.37 (SD ±1.07) years, whereas the mean age at onset of schizophrenia was 10.47 (SD ±0.91) years ([Table 2]). The onset of illness was acute (<6 months) in nine (47.4%) patients and insidious (>6 months) in 10 (52.6%) patients. The mean duration of untreated psychosis (DUP) was 10.47 (SD ±10.89) months, whereas the mean duration of illness was 46 (SD ±12.28) months ([Table 2]).
[Table 2] also shows that the mean BPRS-C from the beginning of the study was 49.11 (SD ±10.84), the mean of the negative subscale of PANSS was 29.00 (SD ±8.85), and the mean of the positive subscale was 28.16 (SD ±8.34). The CGAS at the start of the study was 32.95 (SD ±7.51).
Outcome of childhood-onset schizophrenia
The data show that 31.6% of the participants had good outcome in terms of their functioning, 42.1% had moderate outcome, whereas 26.3% had poor outcome. Using Spearman’s correlation, the presence of less negative symptoms (r=0.53; P=0.020) was significantly associated with good outcome.
Factors associated with poor outcome
Participants with poor outcome were more likely to have a record of history of perinatal complications compared with those with moderate to good functioning at 3 years of treatment (50 vs. 10%). This was statistically significant (χ2=4.108; P=0.043). Those that had poor functioning had more negative symptoms score on PANSS at 37.40 (SD ±8.62) compared with 26.00 (SD ±6.98) for participants that eventually had moderate to good outcome ([Table 4]). This was also statistically significant (t-test=2.957; P=0.009). Individuals with poor outcome had 13.86 (SD ±10.83) months of DUP compared with 1.00 (SD ±0.78) months of DUP. This was statistically significant (t-test=2.607; P=0.018). Moreover, the participants with poor outcome had longer duration of illness at 59.57 (SD ±12.51) months compared with 46.00 (SD ±0.78) months. This difference was statistically significant (t-test=2.382; P=0.029).
|Table 3 Factors associated with poor outcome in childhood-onset schizophrenia|
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|Table 4 Factors associated with poor outcome in childhood-onset schizophrenia|
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Sex of the patients was not associated with poor outcome even though more males had poor outcome at 33.3% compared with 20% for females (χ2=0.435; P=0.509). Other factors like family history of mental illness, history of trauma, delayed developmental milestone, comorbid psychiatric conditions, and presence of life-events in the last 1 year were not associated with poor outcome ([Table 3]). The mean of the age of onset was 10.38 (SD ±0.45) years for those with poor prognosis, and was lower than 10.80 (SD ±1.01) years for those with moderate to good outcome ([Table 4]). This difference, however, was not statistically significant (t-test=0.936; P=0.362).
Logistic regression on factors associated with poor outcome
The factors that were associated with poor outcome in COS were put into a logistic regression analysis. These factors included perinatal complications, DUP, duration of illness, and having predominant negative symptoms. All the four factors did not show further association on logistic regression.
| Discussion|| |
A slightly larger number of females completed the present study compared with males, which is in keeping with other studies (Eggers and Bunk, 1997; Hassan and Taha, 2011), but a number of studies have reported a male predominance (Lay et al., 2000; Remschmidt et al., 2000). This may just be as a result of referral bias. Over the 3 years of follow-up in our study, the dropout rate was 16.7%, which is similar to that of a number of outcome studies on early-onset psychosis (Asarnow et al., 1994; Ledda et al., 2009). High dropout rates are common in psychiatric outcome studies (Harrison et al., 2001).
In the present study, 31.6% had good outcome, 42.1% had moderate outcome, and 26.3% had poor outcome. In an Egyptian study, as in this study, patients with poor outcome comprised 25% of the sample, but the percentage for individuals with good outcome was low at 27% and that of individuals with moderale outcome was high at 48.7% (Hassan and Taha, 2011). The results of our study are similar to that of other studies that reported a fourth of their patients with poor outcome (Reichert et al., 2008; Ledda et al., 2009). This is in contrast to a systematic review that reported that only 15.4% of the patients with early-onset schizophrenia had good outcome, 24.5% had moderate outcome, and 60.1% had poor outcome (Clemmensen et al., 2012). The relatively better remission in this study could be attributed to the shorter duration of the follow-up (Hassan and Taha, 2011), the use of different outcome measures, and possibly to the adult pattern of better outcome of schizophrenia in developing countries (Hopper et al., 2007; Haro et al., 2011).
Factors associated with poor outcome in this study included longer DUP, longer duration of illness, perinatal complications, and more negative symptoms. A number of studies have reported that longer DUP, like in this study, is associated with poor outcome in COS patients (Hassan and Taha, 2011; Fraguas et al., 2014; Díaz-Caneja et al., 2015). This brings the idea of early intervention in COS into consideration, as it may be more cost effective and also reduce further burden in adulthood (McCrone et al., 2013; Patton et al., 2014).
Negative symptoms were associated with poor outcome in this study. This was also the case in a systematic review of predictors of outcome in early-onset psychosis, where the presence of prominent negative symptoms was a risk factor for poor outcome (Díaz-Caneja et al., 2015). In addition, those with perinatal complications had poor negative outcome in this study. It has been proposed that premorbid difficulties may continue into primary negative symptoms in childhood schizophrenia (Hollis, 2003). Therefore, there may be a greater risk in having poor outcome in individuals with more neurodevelopmental load (Strauss et al., 2012). Thus, the presence of early developmental problems and negative symptoms may be regarded as predictors of functional and clinical outcomes, which also gives more credence to the neurodevelopmental theory of schizophrenia (Fatemi and Folsom, 2009).
| Conclusion|| |
Out of the small sample of COS patients included in the present study, more than a third had good outcome. Factors that were associated with poor outcome included longer DUP, longer duration of illness, perinatal complications, and presence of more negative symptoms at the onset of the illness. There is a need for early diagnosis of COS with optimal intervention given to reduce the burden of the condition.
The authors thank Mallam Danjumai Abdu, the record and health information officer in the Child and Adolescent Mental Health Unit of Aminu Kano Teaching Hospital.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Addington AM, Rapoport JL (2009). The genetics of childhood-onset schizophrenia: when madness strikes the prepubescent. Curr Psychiatry Rep 11:156–161.
Adewuya AO, Ola BA, Aloba OO (2007). Prevalence of major depressive disorders and a validation of the Beck Depression Inventory among Nigerian adolescents. Eur Child Adolesc Psychiatry 16:287–292.
American Psychiatric Association (1994). Diagnostic and statistical manual of mental disorders. 4th ed. revised. Arlington, VA: American Psychiatric Publishing.
American Psychiatric Association (2013). Diagnostic and statistical manual of mental disorders (5th ed. revised). Arlington, VA: American Psychiatric Publishing.
Amminger GP, Henry LP, Harrigan SM, Harris MG, Alvarez-Jimenez M, Herrman H et al.
(2011). Outcome in early-onset schizophrenia revisited: findings from the Early Psychosis Prevention and Intervention Centre long-term follow-up study. Schizophr Res 131:112–119.
Asarnow JR, Tompson MCGoldstein MJ (1994). Childhood-onset schizophrenia: a follow-up study. Schizophr Bull 20:599–617.
Asarnow JR, Tompson MC, McGrath EP (2004). Annotation: childhood-onset schizophrenia: clinical and treatment issues. J Child Psychol Psychiatry 45:180–194.
Bakare MO, Agomoh AO, Eaton J, Ebigbo PO, Onwukwe JU (2011). Functional status and its associated factors in Nigerian adolescents with bipolar disorder. Afr J Psychiatry (Johannesbg) 14:388–391.
Bartlett J (2004). Childhood-onset schizophrenia: what do we really know? Health Psychol Behav Med 2:735–747.
Clemmensen L, Vernal DL, Steinhausen HC (2012). A systematic review of the long-term outcome of early onset schizophrenia. BMC Psychiatry 12:150.
Díaz-Caneja CM, Pina-Camacho L, Rodrígues-Quiroga A, Fraguas D, Parellada M, Arango C. (2015). Predictors of outcome in early-onset psychosis: a systematic review. npg Schizophrenia 1:14005.
Eggers C, Bunk D (1997). The long-term course of childhood-onset schizophrenia: a 42-year followup. Schizophr Bull; 23:105–117.
Fatemi SH, Folsom TD. (2009). The neurodevelopmental hypothesis of schizophrenia, revisited. Schizophr Bull; 35:528–548.
Fraguas D, Del Rey-Mejías A, Moreno C, Castro-Fornieles J, Graell M, Otero S et al.
(2014). Duration of untreated psychosis predicts functional and clinical outcome in children and adolescents with first-episode psychosis: a 2-year longitudinal study. Schizophr Res 152:130–138.
Gonthier M, Lyon MA (2004). Childhood-onset schizophrenia: an overview. Psychol Sch 41:803–811.
Haro JM, Novick D, Bertsch J, Karagianis J, Dossenbach M, Jones PB (2011). Cross-national clinical and functional remission rates: Worldwide Schizophrenia Outpatient Health Outcomes (W-SOHO) study. Br J Psychiatry 199:194–201.
Harrison G, Hopper K, Craig T, Laska E, Siegel C, Wanderling J et al.
(2001). Recovery from psychotic illness: a 15- and 25-year international follow-up study. Br J Psychiatry 178:506–517.
Hassan GA, Taha GR (2011). Long term functioning in early onset psychosis: two years prospective follow-up study. Behav Brain Funct 7:28.
Hollis C (2003). Developmental precursors of child- and adolescent-onset schizophrenia and affective psychoses: diagnostic specificity and continuity with symptom dimensions. Br J Psychiatry 182:37–44.
Hopper K, Harrison G, Janca A, Sartorius N. editors. (2007). Recovery from schizophrenia: an international perspective London, UK: Oxford University Press.
Jarbin H, von Knorring AL (2003). Diagnostic stability in adolescent onset psychotic disorders. Eur Child Adolesc Psychiatry 12:15–22.
Kaufman J, Birmaher B, Brent D, Rao U, Ryan N(1996). The schedule for affective disorders and schizophrenia for school-age children. Pittsburgh, PA: University of Pittsburgh Medical Center.
Kay SR, Fiszbein A, Opler LA (1987). The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 13:161–176.
Lay B, Blanz B, Hartmann M, Schmidt MH (2000). The psychosocial outcome of adolescent-onset schizophrenia: a 12-year followup. Schizophr Bull 26:801–816.
Ledda MG, Fratta AL, Pintor M, Zuddas A, Cianchetti C (2009). Early-onset psychoses: comparison of clinical features and adult outcome in 3 diagnostic groups. Child Psychiatry Hum Dev 40:421–437.
Maydell RJ, van der Walt C, Roos JL, Scribante L, Ladikos A (2009). Clinical characteristics and premorbid variables in childhood-onset schizophrenia: a descriptive study of twelve cases from a schizophrenia founder population. Afr J Psychiatry (Johannesbg) 12:144–148.
McCrone P, Singh SP, Knapp M, Smith J, Clark M, Shiers D, Tiffin PA (2013). The economic impact of early intervention in psychosis services for children and adolescents. Early Interv Psychiatry 7:368–373.
Overall JE, Pfefferbaum B (1982). The brief psychiatric rating scale for children. Psychopharmacol Bull 18:10–16.
Paruk S, Ramiall S, Burns JK (2009). Adolescent-onset psychosis: a 2-year retrospective study of adolescents admitted to a general psychiatric unit. S Afr J Psychiatr 15:86–92.
Patton GC, Coffey C, Romaniuk H, Mackinnon A, Carlin JB, Degenhardt L et al.
(2014). The prognosis of common mental disorders in adolescents: a 14-year prospective cohort study. Lancet 383:1404–1411.
Rapoport JL, Inoff-Germain G (2000). Update on childhood-onset schizophrenia. Curr Psychiatry Rep 2:410–415.
Reichert A, Kreiker S, Mehler-Wex C, Warnke A (2008). The psychopathological and psychosocial outcome of early-onset schizophrenia: preliminary data of a 13-year follow-up. Child Adolesc Psychiatry Ment Health 2:6.
Remschmidt HE, Martin M, Hennighausen K, Schulz E (2000). Treatment and rehabilitation. In Remschmidt HE editor. Schizophrenia in children and adolescents
. New York, NY: Cambridge University Press 192–267.
Remschmidt H, Martin M, Fleischhaker C, Theisen FM, Hennighausen K, Gutenbrunner C, Schulz E (2007). Forty-two-years later: the outcome of childhood-onset schizophrenia. J Neural Transm (Vienna) 114:505–512.
Röpcke B, Eggers C (2005). Early-onset schizophrenia: a 15-year follow-up. Eur Child Adolesc Psychiatry 14:341–350.
Shafer SQ, Shaffer D, O’Connor PA, Stokman CJ (1983). Hard thoughts on neurological soft signs. In Rutter M, editor. Developmental neuropsychiatry. New York, NY: Guilford Press; 133–143.
Shahrivar Z, Kousha M, Moallemi S, Tehrani-Doost M, Alaghband-Rad J (2010). The reliability and validity of Kiddies–Schedule for Affective Disorders and Schizophrenia – Present and Lifetime Version–Persian Version. Child Adolesc Ment Health 15:97–102.
Strauss GP, Allen DN, Miski P, Buchanan RW, Kirkpatrick B, Carpenter WT Jr (2012). Differential patterns of premorbid social and academic deterioration in deficit and nondeficit schizophrenia. Schizophr Res 135:134–138.
Taylor EH (1998). Advances in the diagnosis and treatment of children with serious mental illness. Child Welfare 77:311–332. 1998
Tunde-Ayinmode M, Adegunloye O, Ayinmode B, Abiodun O (2012). Psychiatric disorders in children attending a Nigerian primary care unit: functional impairment and risk factors. Child Adolesc Psychiatry Ment Health 628.
Umar MU, Obindo TJ, Omigbodun OO (2015). Prevalence and correlates of ADHD among adolescent students in Nigeria. J Atten Disord[Epub ahead of print]
[Table 1], [Table 2], [Table 3], [Table 4]