• Users Online: 308
  • Home
  • Print this page
  • Email this page
Home Current issue Archives Ahead of print Search Subscribe Instructions Submit article About us Editorial board Contacts Login 
ORIGINAL ARTICLE
Year : 2018  |  Volume : 39  |  Issue : 1  |  Page : 28-34

Cognitive dysfunction in depressive and mixed episodes of bipolar disorder and major depressive disorder: is there a difference? egyptian experience


Department of Neurology and Psychiatry, Faculty of Medicine, University of Alexandria, Alexandria, Egypt

Correspondence Address:
Hesham A Sheshtawy
Department of Neurology and Psychiatry, Faculty of Medicine, University of Alexandria, Alexandria, 21525
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ejpsy.ejpsy_27_17

Rights and Permissions

Background Depressive episodes are present in both bipolar disorder (BD) and major depressive disorder (MDD). Do cognitive dysfunction symptoms of depressive episode differ according to the disorder (MDD or BD)? Aim of the work This work aimed to study the cognitive functions among patients with BD (depressive or mixed) and MDD during relapse. Patients and methods This study included 90 patients during relapse diagnosed according to Diagnostic and Statistical Manual of Mental Disorders, 4th ed., Text Revision (DSM-IV-TR) (30 bipolar mixed, 30 bipolar depression, and 30 major depression) and 30 control participants. They were compared in terms of the severity of depression (using the Hamilton Depression Rating Scale), working memory (using the digit span test), processing speed (using the digit symbol test and trail making test A), verbal fluency (using the verbal fluency test), and executive function (using trail making test B). Results The scores of BD patients were significantly worse than those of MDD patients in digit span tests (forward and backward), digit symbol test, verbal fluency test, and trail making tests (A and B). No significant difference was found between bipolar depression patients and bipolar mixed patients in the patterns of cognitive dysfunctions and the severity of cognitive dysfunctions. Conclusion Bipolar patients experience significantly greater impairment than major depression patients. Other differentiators between the two disorders were that BD have lower age of illness onset, higher number of previous episodes, higher numbers of previous hospitalizations, and greater presence of psychotic features than MDD.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed34    
    Printed0    
    Emailed0    
    PDF Downloaded19    
    Comments [Add]    

Recommend this journal