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 Table of Contents  
ORIGINAL ARTICLE
Year : 2020  |  Volume : 41  |  Issue : 1  |  Page : 25-32

Depressive and anxiety symptoms in relation to sexual dysfunction in female patients with psoriasis


1 Department of Andrology, Sexology and STDS, Faculty of Medicine, Cairo University, Cairo, Egypt
2 Department of Andrology, Sexology and STDS, Beni-Suef University, Beni-Suef, Egypt
3 Department of Dermatology, Beni-Suef General Hospital, Beni-Suef, Egypt
4 Psychiatry, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt

Date of Submission14-Oct-2019
Date of Decision30-Oct-2019
Date of Acceptance03-Nov-2019
Date of Web Publication22-Jan-2020

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ejpsy.ejpsy_36_19

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  Abstract 


Background Psoriasis is a chronic, inflammatory cutaneous disease with worldwide estimated prevalence ranging from 0.9 to 8.5%. Psoriasis has been associated with psychological problems, including low self-esteem, depression, anxiety, sexual dysfunction, or suicidal ideation.
Objectives To assess depressive and anxiety manifestation in relation to sexual functions in female patients with psoriasis compared with healthy controls.
Patients and methods One hundred female patients with psoriasis were recruited from the dermatology outpatient clinic of the medical faculty of Beni-Suef University, and 80 female participants were included as a control group. The study was conducted after obtaining the approval of the ethical committee of the Faculty of Medicine, Beni-Suef University. All participants were subjected to the following: Beck Depression Inventory, Beck Anxiety Inventory, and Female Sexual Function Index.
Results Patients with psoriasis showed a highly significant depressive and anxiety symptoms and scores on Beck Depression Inventory and Beck Anxiety Inventory, respectively, compared with control group (65 vs. 26.1% and 74 vs. 66.1%, respectively). Psoriasis cases exhibited a statistically significant decrease in all domains of Female Sexual Function Index compared with control group, except satisfaction. Cases with sexual dysfunction showed significantly higher anxiety symptoms and scores (but not depression) than cases with normal sexual dysfunction.
Conclusion Patients with psoriasis showed more depressive and anxiety symptoms. Moreover, they showed more sexual dysfunction, particularly on the desire, arousal, lubrication, and orgasm components of sexual function in female patients. Sexual dysfunction is associated with anxiety but not with depression in female patients with psoriasis.

Keywords: anxiety, depression, female sexual function, psoriasis


How to cite this article:
Hassanin AM, Ismail NN, Kaddah AN, Ebrahiem AA, Ezzat Abd Elhakim AA. Depressive and anxiety symptoms in relation to sexual dysfunction in female patients with psoriasis. Egypt J Psychiatr 2020;41:25-32

How to cite this URL:
Hassanin AM, Ismail NN, Kaddah AN, Ebrahiem AA, Ezzat Abd Elhakim AA. Depressive and anxiety symptoms in relation to sexual dysfunction in female patients with psoriasis. Egypt J Psychiatr [serial online] 2020 [cited 2020 Feb 26];41:25-32. Available from: http://new.ejpsy.eg.net/text.asp?2020/41/1/25/276398




  Introduction Top


The common embryological origin of skin and central nervous system has led to the assumption that their disorders affect each other. Dermatological clinics have higher prevalence of psychiatric morbidity in dermatology patients than the general population. At least one-third of patients seen in dermatology clinics present with a complaint that involves a significant psychological component (Filakovic et al., 2008). Common psychiatric conditions seen in patients with skin diseases may present with both primary psychiatric disorders and psychiatric disorders secondary to dermatologic pathology (Wakkee and Nijsten, 2009).

Psoriasis, a chronic erythematosquamous dermatitis that affects ∼2–3% of the population, is characterized by abnormal keratinocyte hyperproliferation, which makes thickening of the epidermis and of the stratum corneum. Psoriasis vulgaris accounts for 90% of the psoriasis cases (Coimbra and Santos-Silva, 2015).

Psoriasis has been associated with different psychological problems, including low self-esteem, depression, anxiety, sexual dysfunction, or suicidal ideation (Dubertret et al., 2006). The effect of psoriasis upon sexual function seems to be substantial, and it can result in significant alterations in quality of life (Rieder and Tausk, 2012). The prevalence of depression and anxiety in those with psoriasis is higher than that observed in the general population. Psychiatric morbidity is higher, and quality of life scores are lower (Ghajarzadeh et al., 2012).

One might attribute the association between psoriasis and mood disorders as simply resulting from the related embarrassment, shame, and social anxiety incurred from the physical manifestations of disease; however, the prevalence of mood symptoms in psoriasis is higher than that observed with many other disfiguring skin disorders (Kumar et al., 2013). Sexual dysfunction is defined as difficulty experienced by an individual or couple during any stage of normal sexual activity, including physical pleasure, desire, preference, arousal, or orgasm; it can have a profound effect on an individual’s quality of sexual life (Eden and Wylie, 2009). Female sexual complaints are common. However, it is difficult to accurately determine their prevalence worldwide. Western studies use different definitions of normal and abnormal sexual functions (SF) and use heterogeneous populations (Latif and Diamond, 2013). Some research studies have pointed out some factors that could be responsible for female sexual dysfunction (FSD), including depression/anxiety, stress, drug or alcohol abuse, interpersonal relationship issues, such as partner performance and technique, or lack of partnership quality (Jyoti et al., 2001).

This study aimed at assessment of depressive and anxiety symptoms and sexual functions in female patients with psoriasis and also to investigate the relation between both depressive and anxiety symptoms and the sexual dysfunction in those patients.


  Patients and methods Top


Study design and setting

This was an observational case–control study conducted between 2017 and 2018 in the Dermatology Departments of Beni Suef General Hospital and University Hospital to assess depressive and anxiety manifestations and its relation to the SF in a sample of women with psoriasis. The Research Ethical Committee (REC) of Beni Suef Faculty of Medicine approved the study protocol.

Study participants

A total of 100 consecutive females with psoriasis (patient group) and 80 healthy age-matched and sex-matched volunteers (control group) who expressed interest to participate and met the inclusion criteria registered below were included.

Inclusion criteria

The patients and controls were included only if they were between 18 and 45 years, married, and sexually active during the past 6 months, as well as able to read and give consent. The sample was restricted to married women because of cultural sensitivities discussing sexual disorders in unmarried females. Patients were recruited from females attending the dermatology outpatient clinic of the formerly mentioned hospitals. Overall, 50% the of patients were untreated and 50% were treated by 25% topical and 25% phototherapy according to treatment protocol. Control group included normal volunteer women, selected from the family members or relatives, who accompanied the patients to the hospital.

Exclusion criteria

Unmarried, divorced, widowed, and separated females were excluded. Moreover, participants having chronic debilitating disease, participants on antidepressants or known to have history of other psychiatric disorders and other drugs that are known to interfere with sexual function, postmenopausal women, and those having husbands with sexual disorders were excluded.

All participants in the study were subjected to the following:
  1. All patients were diagnosed using the Structured Clinical Interview for DSM-IV Disorders (SCID-I) (Firstet al., 2002), which had been modified to DSM-V clinical criteria by the same psychiatrist taking care of the patients.
  2. A demographic and clinical data collection form: it was designed by the researchers to gather information about the characteristics of the study participants (age, educational level, number of children, menstrual history, duration of marriage, etc.).
  3. The Arabic version of Female Sexual Function Index (FSFI): the FSFI is a 19-item questionnaire that assesses the SF or problems during the past 4 weeks. Specific domains analyzed in FSFI are the quality of desire (questions 1 and 2), arousal (questions 3–6), lubrication (questions 7–10), orgasm (questions 11–13), satisfaction (questions 14–16), and degree of pain (questions 17–19) (Rosenet al., 2000). The Arabic validated version of FSFI (Aniset al., 2011) was used to assess the SF of the patients and controls. It is a self-administered questionnaire.


Scoring: each domain is scored on a scale of 0 or 1–5. The score of each domain is calculated through summing up the scores of that domain’s questions and multiplying the obtained number by the multiplier factor of that domain. Multiplier factors of 0.6, 0.4, and 0.3 are used for domains, including 2, 3, and 4 questions, respectively. In general, each domain has a minimum (0–1.2/1.8) and a maximum (6). The SF total score is obtained from the sum of the scores of all the domains and is ranged from 2 to 36 (Rosen et al., 2000; Jamali et al., 2014). Regarding cutoff values, FSFI total score of 26.55 was found to be the optimal cutoff score for differentiating women with and without sexual dysfunction. The cutoff scores to determine the presence of difficulties in a particular domain of the FSFI are as follows: less than 4.28 in the desire domain, less than 5.08 in the arousal domain, less than 5.45 in the lubrication domain, less than 5.05 in the orgasm domain, less than 5.04 in the satisfaction domain, and less than 5.51 in the pain domain (Wiegel et al., 2005). Individual domain score and overall FSFI scores were compared between the study groups.

Beck Depression scale by Beck et al. (1961) and Arabic version by Abdel-Khalek (1998): this is a self-report scale designed to assess DSM-IV-defined symptoms of depression such as sadness, guilt, loss of interest, social withdrawal, increase and decrease in appetite or sleep, suicidal ideation, and other behavioral manifestations of depression over time to monitor symptoms and to assess response to therapeutic interventions. It has acceptable degree of validity, as it evaluates a wide variety of symptoms and attitudes associated with depression.

The inventory is composed of 21 statements on a four-point scale, with the patient selecting the one that best matches his or her current state. Each statement corresponds to a specific behavioral manifestation. Responses are scored on a 0–3 scale, corresponding to no, mild, moderate, or severe disturbance. The score range varies from 0 to 63, where a higher score indicates greater depression severity. According to Beck et al. (1996), the scoring range is as follows: 0–13 indicate no or minimal depression, 14–19 indicate mild depression, 20–28 indicate moderate depression, and 29–63 indicate severe depression.

Beck Anxiety scale by Beck et al. (1988) and Arabic version by Al-Issa et al. (2000): Beck Anxiety Inventory (BAI) is a 21-item multiple-choice self-report inventory that measures the severity of an anxiety. Each of the items on the BAI is a simple description of a symptom of anxiety in one of its four expressed aspects: (a) subjective (e.g. ‘unable to relax’), (b) neurophysiologic (e.g. ‘numbness or tingling’), (c) autonomic (e.g. ‘feeling hot’), or (d) panic-related (e.g., ‘fear of losing control’). It has acceptable reliability and validity.

Respondents are asked to report the extent to which they have been bothered by each of the 21 symptoms in the week preceding (including the day of) their completion of the BAI. Each symptom item has four possible answer choices: not at all, mildly (it did not bother me much), moderately (it was very unpleasant, but I could stand it), and severely (I could barely stand it). The clinician assigns the following values to each response: not at all=0, mildly=1, moderately=2, and severely=3. The values for each item are summed yielding an overall or total score for all 21 symptoms that can range between 0 and 63 points.

Scores from 0 to 7 indicate a minimal level of anxiety. Scores from 8 to 15 indicate mild anxiety. Scores from 16 to 25 indicate moderate anxiety. Scores from 26 to 63 indicate severe anxiety.

Statistical analysis

Numerical data were expressed as mean+SD. Qualitative data were expressed as frequency and percentage. The characteristics of the two groups were compared by the χ2 test for qualitative variables and the Student’s t test for quantitative variables. One-way analysis of variance was used to analyze the difference in multiple groups. The relation between different numerical variables was tested using the Pearson correlation (r). The IBM statistical package for the social science (IBM SPSS), version 20 (SPSS Inc., Chicago, Illinois, USA) was used for statistical analysis. The level of statistical significance was set as P value less than 0.05.

The sample size was calculated with the aid of an online available software (http://www.stat.ubc.ca/∼rollin/stats/ssize/). The desired power was set at 0.80 and error at 0.05. The analysis generated a minimum required sample size of 73 for each group, but there was a chance to recruit more patients (180 in totals) to reinforce our findings.

Ethical considerations

A written consent after explanation of the study to the participating women was obtained, and they were ensured of confidentiality.


  Results Top


The present study included 100 female patients with an average age of 32.91±7.07 years, and 80 matched control females with an average age of 31.75±7.50 years (P>0.05). There is no statistically significant difference between cases and controls regarding age, education, regularity of menstrual cycle, age of menarche, age of marriage, and duration since last pregnancy (P>0.05) and shows statistically significant difference regarding number of children, as cases showed less number of children (P<0.05), as shown in [Table 1].
Table 1 Demographic and clinical characteristics of the study groups

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[Table 2] shows that there was a statistically significant difference between case and control group regarding severity of depressive and anxiety symptoms (P<0.05).
Table 2 Comparison between case and control groups regarding severity of depressive and anxiety symptoms

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[Table 3] illustrates that there was a highly significant difference between the two groups regarding the total as well as individual domain scores, with lower scores among patients (P<0.05), except satisfaction domain.
Table 3 Comparison of sexual function among cases and controls

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[Table 4] shows a statistically significant difference between female sexual dysfunctions and types of psoriasis, as sexual dysfunction more in genital>vulgaris>palmoplantar (P<0.05). However, there was no statistically significant difference between female sexual dysfunctions and sociodemographic variables, disease course, duration, and treatment modalities among patients (P>0.05).
Table 4 Comparison between sexual functions and sociodemographic variables in the patients (N=100)

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[Table 5] shows a statistically significant difference between sexual dysfunctions and severity of anxiety symptoms as (P<0.05). However, there was no statistically significant difference between severity of depressive symptoms and sexual dysfunctions.
Table 5 Comparison between sexual functions and severity of depressive and anxiety symptoms among patients (N=100)

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[Table 6] shows a highly statistically significant negative correlation between sexual dysfunctions reported by FSFI and both of Beck Anxiety and Depression Inventory scores (P<0.001).
Table 6 Correlation between sexual dysfunction and both depressive, anxiety scores

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  Discussion Top


The present study included 100 female patients, with an average age of 32.91±7.07 years, and 80 matched control females, with an average age of 31.75±7.50 years (P>0.05).

There was no statistically significant difference between cases and controls regarding age, education, regularity of menstrual cycle, age of menarche, age of marriage, and duration since last pregnancy (P>0.05) and shows statistically significant difference regarding numbers of children, as cases showed less number of children (P<0.05) ([Table 1]).

In the current study, cases showed more severe depressive and anxiety symptoms as compared with the control group (P<0.05), as mild, moderate, and severe depressive symptoms were more common among patients compared with controls, with P value less than 0.05, as 21 (26.2%) of controls and 65 (65%) of cases have depression and one (1.2%) of controls and 23 (23%) of cases have severe depression. Cases with psoriasis in this study were more likely to have anxiety. Moderate and severe anxiety were more common among patients compared with controls, with significant difference (P<0.05), as only 5% of controls have severe anxiety compared with 23% of cases have severe anxiety ([Table 2]).

These findings are in line with a UK population-based cohort study of 146 042 patients which demonstrated an increased incidence of diagnoses of depression, anxiety, and suicidality in psoriasis; the authors estimated that more than 10 400 diagnoses of depression, 7100 diagnoses of anxiety, and 350 diagnoses of suicidality were attributable to psoriasis each year (Kurd et al., 2010). In another study which stated that with exclusion of demographic characteristics such as age, sex, job, and education, the risk of psoriatic disease related to anxiety and depression would have been 4.6 times (2.11–11.7) and six times (2.37–17.41) of healthy participants, respectively (Golpour et al., 2012).

In this study, cases with psoriasis exhibited more significant sexual dysfunction in all domains and scored lower scores on FSFI in all domains except satisfaction as compared with controls (P<0.001). It is found that among cases, total FSFI score was 23.2±5.5, desire 3.7±1.1, arousal 3.7±1, lubrication 3.7±1.1, orgasm 4±1.2, satisfaction 4.4±1.3, pain 3.9±1.2; all showed significant dysfunction, as P value was less than 0.001, except satisfaction ([Table 3]). These results are comparable to the results of the study conducted by Mercan et al. (2008), who found that sexual dysfunctions were more common in the group of patients with psoriasis than in the control group. In another study done by Molina-Leyva et al. (2015), it was reported that the prevalence of sexual dysfunction was 53.7% in patients with psoriasis versus 17.5% in healthy volunteers (P<0.001). The frequency of sexual dysfunction, in the crude analysis, was higher in patients with psoriasis compared with controls (odds ratio=5.5, 95% confidence interval, 2.6–11.3, P<0.001) (Molina-Leyva et al., 2015).

Psoriasis itself may play an important role in sexual dysfunction development in these patients. In this sense, patients with involvement of areas of sexual impact (ASI), frequently affected by psoriasis and corelated with important stigmatization, are more likely to experience sexual dysfunction than patients who are free of lesions in these areas (Schmid-Ott et al., 1999; Wolkenstein, 2006).

This association was independent of anxiety or depression levels, and these areas were thus referred to ASI. Physiological and pathological changes in body image, such as pregnancy or surgical sequelae, have been linked to sexual dysfunction through the impairment of self-esteem and sexual distress (Nobre and Pinto-Gouveia, 2008; Pauls et al., 2008; Rossen et al., 2012).

Sexual dysfunction secondary to psoriasis affecting ASI could probably be facilitated by feelings of stigmatization, shame, low self-esteem, and increased sexual distress (Sanchez and Kiefer, 2007; Seikowski et al., 2008; Hrehorów et al., 2012).

Regarding comparison between patient with sexual dysfunction and patient without sexual dysfunction in sociodemographic characteristics (age, education, number of children, menstrual regularity, menarche age, and marriage duration), the two groups were comparable, as P value in all was more than 0.05, and these results are consistent with findings of a study by Golpour et al. (2012), who stated that the case group of patients with psoriasis was assessed for relationship between depression and sex, education level, and employment, but there was no statistically significant difference (P>0.05).

However, comparison regarding clinical data and disease characters revealed that cases with sexual dysfunctions were more in genital type of psoriasis; moreover, cases with sexual dysfunctions demonstrated a significant more frequent exacerbations and/or progressive course than cases without sexual dysfunctions (P<0.05). However, there was no statistically significant difference between sexual dysfunction, disease duration, as well as treatment modalities (P>0.05) ([Table 4]). These findings are in agreement with other studies, such as the study done by Meeuwis et al. (2011), who showed the effect of genital psoriasis on sexual health and quality of life (n=487) and found that psoriasis has a detrimental effect on quality of life and sexual health. Patients with genital lesions reported even significantly worse quality of life than patients without genital lesions; quality of life (mean±SD) scores were 8.5±6.5 versus 5.5±4.6, respectively (P<0.0001). Sexual distress and dysfunction were particularly prominent in women (reported by 37.7 and 48.7% of the female patients, respectively). Sexual distress is especially high when genital skin is affected. Sexual distress (mean±SD) scores in patients with genital lesions were 16.1±12.1 vs. 10.1±9.7 in patients without genital lesions (P=0.001) (Meeuwis et al., 2011). In the current study while investigating the relation between depression and anxiety symptoms and sexual dysfunction in psoriatic patients, it was found that patients with sexual dysfunction and patients with no sexual dysfunction were comparable regarding depression scores on Beck Depression Inventory (P>0.05)([Table 5]). This result was consistent with the results of a study of Türel Ermertcan et al. (2006) which was conducted on 66 female participants (39 with psoriasis and 27 healthy volunteers as a control group), and FSFI total score was found to be significantly decreased in female psoriatic patients without depression and psoriatic patients plus depression compared with healthy controls (24.09±5.33 vs. 24.25±4.52 vs. 28.12±3.48, respectively, P=0.004). However, FSFI score was not significantly different between patients with psoriasis without depression and those with psoriasis plus depression (P>0.05). The results of the study demonstrated that patients with psoriasis, especially females have distinct sexual dysfunction compared with healthy controls, and coexistent depression has no additional negative effect on sexual dysfunction in the patients. Patients with psoriasis should be evaluated in terms of sexual function to provide a better quality of life (Türel Ermertcan et al., 2006).

Patients with sexual dysfunction experienced more severe anxiety symptoms than patients without sexual dysfunction (P<0.05) ([Table 5]). These results were consistent with Fortune et al. (2003), who found that the prevalence of anxiety is higher than depression in psoriatic patients. Even psoriatic patients have reported significantly higher degrees of anxiety than other chronic diseases such as cancers. Furthermore, the severity of anxiety would be greater in patients with palms and soles psoriasis (Fortune et al., 2003).

Correlation of the Beck’s Depression and Anxiety scores with the FSFI total score indicated significant negative correlation (R, −0.446d, P<0.001, and R, −0.585, P<0.001, respectively) ([Table 6]). These results indicated the negative effect of depression and anxiety on female sexual function. These results were in line with Molina-Leyva et al. (2015) who reported that the frequency of anxiety symptoms was higher in patients with psoriasis than in the overall population (50 vs. 20%, respectively; odds ratio, 4.0, 95% confidence interval, 1.9–8.0, P<0.001). The same was observed for symptoms of depression. Although the absolute magnitude was lower than that of anxiety (32.5 vs. 4.9% for psoriasis patients and healthy volunteers respectively), the relative magnitude of the association was higher (odds ratio, 9.1, 95% confidence interval, 3.0–27.7, P<0.001). As nearly all the participants with symptoms of depression also presented symptoms of anxiety, a new variable, ‘symptoms/evidence of anxiety and/or depression,’ which included all the subjects with a cut-off score higher than 7 on the hospital anxiety depression scale (HADS) anxiety subscale or HADS depression subscale, was coded. Therefore, there seemed to be a correlation between psoriasis, symptoms of anxiety and/or depression, and sexual dysfunction (Molina-Leyva et al., 2015).

We acknowledge some methodological weakness in our study: (a) the cases had lesser number of children than controls. (b) We have included relatively chronic cases of psoriasis in the analyses but not new cases, and therefore, the relational hypothesis should be supported by investigating new cases as well. However, the magnitude of the found associations is very strong, and we should consider the potential role of the psoriasis itself on sexual dysfunction occurring in affected patients. A larger study with incident cases of psoriasis should be performed to comprehensively explore the relational hypothesis.

In conclusion, we have found a high frequency of sexual dysfunction problems in female patients with psoriasis. We suggest that the assessment of sexual function should be a part of the comprehensive care of patients with moderate to severe psoriasis. Screening and treatment of anxiety and depression, which are quite prevalent in this group of patients, should also be considered because clinical signs of these conditions can significantly impair sexual function.[34]

Acknowledgements

The authors thank all participants in this study.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
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    Tables

  [Table 1], [Table 2], [Table 3], [Table 4], [Table 5], [Table 6]



 

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