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 Table of Contents  
ORIGINAL ARTICLE
Year : 2017  |  Volume : 38  |  Issue : 2  |  Page : 97-104

A study of sociodemographic factors and anxiety: depressive disorders among irritable bowel syndrome patients


1 Department of Psychiatry, Faculty of Medicine, Mansoura University, Mansoura; Madinah Psychiatric Hospital, Madinah, Egypt
2 Department of Psychiatry, Faculty of Medicine, Mansoura University, Mansoura, Egypt
3 Department of Internal Medicine, Faculty of Medicine, Mansoura University, Mansoura; Islamic University Medical Centre, Madinah, Egypt

Date of Submission17-Oct-2016
Date of Acceptance03-Nov-2016
Date of Web Publication5-Jul-2017

Correspondence Address:
Khaled S Sherra
Department of Psychiatry, Mansoura University, Mansoura
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1110-1105.209680

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  Abstract 

Background
Irritable bowel syndrome (IBS) is a highly prevalent functional gastrointestinal disorder. Psychiatric disorders are common among IBS patients and it differs among different cultures. This study was carried out to assess sociodemographic variables and determine the magnitude of anxiety–depressive disorders among IBS patients for proper management.
Patients and methods
In a cross-sectional study, 73 IBS patients were diagnosed (using the criteria of Rome III) from among 400 serial patents attending the gastroenterology clinic at Islamic University Medical Centre (IUMC), Al-Medina Almounawarrha, KSA, in the period from January to December 2015 and were assessed for sociodemographic variables and anxiety–depressive disorders by psychometric tests, the Arabic version of ‘Taylor Manifest Anxiety Scale’ and ‘Beck Depression Inventory Scale’, compared with 73 non-IBS patients.
Results
Of 400 patients who participated in this study, 73 (18.25%) were diagnosed with IBS and 327 (81.75%) were non-IBS patients. In terms of sociodemographic data, IBS patients were matched with non-IBS patients for age, race (different races from different countries), and living condition. Female sex was predominant as regard sex, family history of IBS, emotional stress and traveler’s diarrhea with statistically significant difference. These variables were statistically significant in our study. In terms of lifestyle factors, both groups were matched for smoking and caffeine intake, but IBS patients experienced food hypersensitivity with a tendency to have normal body weight, and to have poor physical exercise and poor quality of sleep with a statistically significant difference compared with the non-IBS patients. For psychometric tests, 46 (63%) out of 73 patients were diagnosed with anxiety–depressive disorders; 16 (22%) had pure anxiety disorders, 18 (24.6%) had depressive disorders, and 12 (26.4%) had comorbid anxiety–depressive disorders.
Conclusion
The high prevalence of anxiety–depressive disorders among IBS patients led us to perform a psychiatric assessment as an important part of the management plan for IBS patients.

Keywords: anxiety, depression, irritable bowel syndrome


How to cite this article:
Elsaied HF, Sherra KS, Mahmoud EHM, Ebrahim MA. A study of sociodemographic factors and anxiety: depressive disorders among irritable bowel syndrome patients. Egypt J Psychiatr 2017;38:97-104

How to cite this URL:
Elsaied HF, Sherra KS, Mahmoud EHM, Ebrahim MA. A study of sociodemographic factors and anxiety: depressive disorders among irritable bowel syndrome patients. Egypt J Psychiatr [serial online] 2017 [cited 2021 Apr 10];38:97-104. Available from: http://new.ejpsy.eg.net/text.asp?2017/38/2/97/209680


  Introduction Top


Irritable bowel syndrome (IBS) is a highly prevalent functional gastrointestinal disorder, with a high health burden and economic expenditure, characterized by chronic abdominal pain accompanied by altered bowel habits (Doshi et al., 2014a, 2014b; Stasi et al., 2014; Lee et al., 2016). IBS is a painful condition associated with significant psychological distress and psychiatric comorbidities, such as higher levels of anxiety or depression and suicidal ideation, with a negative impact on quality of life (Canavan et al., 2014; Stasi et al., 2014). Its consequences are measured in direct costs (medical treatment and procedures) and indirect costs (reduced productivity) (Doshi et al., 2014a, 2014b). Rome III diagnostic criteria are the current gold standard for the diagnosis of IBS patients. According to these criteria, IBS is defined as recurrent abdominal pain or discomfort at least 3 days/month in the last 3 months (with symptom onset at least 6 months before diagnosis) associated with two or more of the following: (a) improvement with defecation, (b) onset associated with a change in the frequency of stool, and (c) onset associated with a change in the form (appearance) of stool. IBS can be subtyped into categories on the basis of the main bowel habit: IBS with constipation (IBS-C), IBS with diarrhea (IBS-D), mixed IBS (IBS-M), and unsubtyped IBS (IBS-US) (Longstreth et al., 2006). Depending on the diagnostic criteria used (Manning, Rome I, Rome II, and Rome III), IBS is estimated to affect ∼11% of the global population. A recent meta-analysis shows the lowest occurrence in South Asia (7%) and the highest occurrence in South America (21%) (Lovell and Ford, 2012). IBS is reported more frequently by women than men in Western countries, the female–male odds ratio being 2 : 1, and seems to be more common in individuals between 20 and 40 years of age. On the basis of the different symptoms observed, the researchers speculated that sex hormones may alter the regulatory mechanisms of the brain–gut–micro biota axis involved in the pathophysiology of IBS (Mulak et al., 2014).

To date, the etiology of IBS remains unclear, without confirmed known causes. However, multiple factors have been considered such as dysregulation of the brain–gut axis, hypothalamic–pituitary–adrenal axis, altered gastrointestinal motility, visceral hypersensitivity, infectious factors, enhanced immunological reactivity, genetic susceptibility, and psychosocial factors (Posserud et al., 2004; Barbara et al., 2011). Stress often worsens the symptoms of patients with IBS. Hyperactivation of the hypothalamic–pituitary–adrenal axis may be involved in IBS pathophysiology (Dinan et al., 2006).Over the past several years, considerable research has evaluated the relationship between IBS and psychiatric disorders. Rates of comorbidity with psychiatric disorders range from 54 to 94% in treatment-seeking patients with IBS (Whitehead et al., 2002; Roy-Byrne et al., 2008).

IBS symptoms seem to be influenced by anxiety and mood disorders (Surdea-Blaga et al., 2012). They may contribute toward predisposition, precipitation, and maintenance of IBS symptoms, and they also influence the clinical outcome (Canavan et al., 2014). One study examined the relationship between IBS and generalized anxiety disorder among IBS patients and healthy individuals and found that 32% of patients with IBS presented with generalized anxiety disorder symptoms compared with other psychological manifestations (Mayer et al., 2001). Also, depression is one of the most diagnosed psychiatric disturbances in IBS patients (Singh et al., 2012). Psychiatric interventions (pharmacologic or psychotherapy) have been proven to be effective in the management of IBS patients’ functioning. Selective serotonin reuptake inhibitors used for anxiety disorders and/or depression can improve the outcome of patients with IBS and associated psychiatric disorders, particularly for the constipation-predominant IBS form (Vaiopoulou et al., 2014).


  Aim of the study Top


This study was carried out to assess sociodemographic variables and determine the magnitude of anxiety–depressive disorders among IBS patients for proper IBS management.


  Patients and methods Top


A cross-sectional study was carried on 73 consecutively diagnosed IBS patients (using Rome III criteria) (Longstreth et al., 2006; NICE, 2008) from among 400 attendants of the gastroenterology and general medicine clinics at Islamic University Medical Centre, Al-Medina Almounawarrha, Kingdom of Saudi Arabia in the period from January to December 2015.

Inclusion criteria

  1. Age: 20–50 years old.
  2. Fulfilling Rome III criteria.
  3. Willing to enroll in the research.


Exclusion criteria

  1. Those older than 50 years of age with recent onset of symptoms (less than 6 months), including a change in bowel habit or those with any red-flag criteria.
  2. Those with coexisting diseases (e.g. intestinal parasites, malignancy, diabetes mellitus cardiovascular, pulmonary, hepatic, or renal disorder).
  3. Those with a family history of colorectal cancer.
  4. Language barrier.


The study was carried out on approval from the Ethics Committee and after obtaining written consents from patients. According to Rome III criteria, IBS patients were categorized into four groups as follows: constipation-predominant IBS (IBS-C), diarrhea-predominant IBS (IBS-D), mixed-IBS (IBS-M), and nonspecified IBS.

IBS patients were subjected to further evaluations including the following:

Full assessment of history

  1. Personal and sociodemographic data, such as age, sex (both men and women), and race (Islamic University including different races).
  2. Family history of IBS.
  3. Red-flag items: Referring to the guidelines for IBS recommended by the American Gastroenterological Association, seven red-flag items are used to distinguish organic intestinal disease from IBS: drastic weight loss, a history of organic bowel disease, a history of digestive surgery, blood in stool, awakening because of abdominal pain during the night, anemia, fever, or arthralgia.
  4. Lifestyle: Number of sleeping hours, smoking habit, exercise, and so on.
  5. Food Frequency Questionnaire inquiring about the frequency of use of different food items such as milk, yogurt, low-fat food, fish, and so on.
  6. Traveler’s diarrhea and whether its presence triggered the first onset of IBS.
  7. Emotional stress in the 6-month period preceding the study: loss of a family member, close friend, and so on.


Clinical examinations (to exclude)

  1. Temperature (fever).
  2. Complexion (pallor or jaundice).
  3. Body weight (significant weight loss).
  4. Abdominal examination (scar of a previous operation, palpable abdominal mass, and examination of the preanal region and rectum in those with rectal bleeding, with possible local pathology including colitis, hemorrhoids, or rectal cancer to be excluded).


Laboratory investigations

  1. Stool analysis: to exclude intestinal parasites and stool occult blood.
  2. Full blood count: ordered in all older patients at first presentation and those with recent onset of symptoms.
  3. Erythrocyte sedimentation rate and C-reactive protein in all those with recent onset of IBS-D.
  4. Endomysial or tissue transglutaminase antibodies especially in IBS-D students from areas of high incidence of celiac disease such as the UK to be excluded.


As there is no identifiable organic cause for IBS, there is a lack of specific diagnostic markers; guideline development groups [for NICE Clinical and The British Society of Gastroenterology’s IBS guidance (Piller et al., 2007; NICE, 2008)] suggest that a positive diagnosis of IBS may generally be made in primary care on the basis of the patient’s symptoms, a lack of alarm features, and minimal laboratory tests (e.g. a full blood count and tests to exclude inflammation and celiac disease).

Study tools

Rome III criteria (criteria fulfilled for the past 3 months with symptom onset at least 6 months before diagnosis) (Longstreth et al., 2006; NICE, 2008)

IBS diagnosis was made on the basis of the English version of ‘Rome III criteria’. Rome III criteria can rationally diagnose IBS in the absence of red flag symptoms. Rome III criteria in the absence of red flag symptoms have a sensitivity of 65%, a specificity of 100%, a positive predictive value of 100%, and a negative predictive value of 76% (NICE, 2008).

Rome III diagnostic criteria for irritable bowel syndrome:

Recurrent abdominal pain or ‘discomfort’ (‘discomfort’ means an uncomfortable sensation not described as pain) at least 3 days a month in the past 3 months, associated with two or more of the following:
  1. Improvement with defecation.
  2. Onset associated with a change in the frequency of stool.
  3. Onset associated with a change in the form (appearance) of stool.


Psychiatric assessment

Judgment on the psychiatric state of the studied IBS patients was carried out using the Arabic version of ‘Taylor Manifest Anxiety Scale’ and ‘Beck Depression Inventory (BDI) Scale’.

The ‘Taylor Manifest Anxiety Scale’, often shortened to ‘TMAS’, is a test of anxiety as a personality trait and was created by Janet Taylor in 1953 to identify patients who would be useful in the study of anxiety disorders (Taylor, 1953). The TMAS originally consisted of 50 true or false questions that a patient answered by reflecting on themselves to determine their anxiety level. Janet Taylor spent her career in the field of psychology studying anxiety and sex development (O’connor et al., 1956). Her scale has often been used to differentiate normal participants from those considered to have pathological anxiety levels. The TMAS has been shown to have high test–retest reliability.

The ‘BDI Scale’, created by Aaron T. Beck, is a 21-question multiple-choice self-report inventory, one of the most widely used psychometric tests to measure the severity of depression. Its development marked a shift among mental health professionals, who had, until then, viewed depression from a psychodynamic perspective, instead of considering it as being rooted in the patient’s own thoughts. The original BDI, first published in 1961 (Beck et al., 1961), consisted of 21 questions on how the patient has been feeling in the last week. Each question has a set of at least four possible responses differing in intensity. The test was also shown to have a high 1-week test–retest reliability (Pearson r=0.93), suggesting that it was not overly sensitive to daily variations in mood (Beck et al., 1996a, 1996b). The test also has high internal consistency (α=0.91) (Beck et al., 1996a, 1996b).

Definitions of psychiatric state assessment of the IBS patients:
  1. Normal: Patients with a Taylor Manifest Anxiety score below 16 and BDI score below 10.
  2. Depression: Patients with BDI scores of 10 or more.
  3. Anxiety: Patients with Taylor Manifest Anxiety scores of 16 or more.
  4. Comorbid: Having both anxiety and depression criteria simultaneously.


IBS patients with (2), (3), and (4) were assessed through psychiatric interviews for appropriate treatment.

Statistical analysis

We used descriptive tools for prevalence analysis, χ2-test for comparing qualitative variables. P-values less than 0.05 were considered statistically significant.


  Results Top


Of 400 patients who participated in this study, 73 (18.25%) were diagnosed with IBS and 327 (81.75%) were non-IBS patients. The mean age of the IBS patients was 32.9±26.8 years and 57.5% of the patients were between 20 and 29 years old. IBS was more common among women, 60.3%, with a statistically significant difference. IBS was common among Saudi people (38.4%), married individuals (50.7%) and university students (53.4%) with good income in 74%. There was a positive family history of IBS, emotional stress, and traveler’s diarrhea preceding the onset of IBS in 82.2, 54.8, and 65.8% of patients, respectively, with a statistically significant difference ([Table 1]).
Table 1: Sociodemographic factors among irritable bowel syndromeS

Click here to view


In terms of the lifestyle factors among IBS patients, 63% had normal BMI, 64.4% had poor physical exercise, 56.2% had poor sleep quality, and 71.2% had food hypersensitivity; all showed a statistically significant difference, whereas no statistical association was found between smoking, consumption of caffeine, and IBS ([Table 2]).
Table 2: Lifestyle factors among irritable bowel syndrome

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Psychometric tests showed that 46 IBS patients (63%) had psychiatric problems, 18 IBS patients (24.6%) had depression, 16 IBS patients (22%) had anxiety and comorbid depression, and 12 IBS patients (16.4%) had anxiety, with no statistically significant difference ([Table 3]).
Table 3: Psychometric tests among irritable bowel syndrome patients and age-matched, sex-matched, and race-matched nonirritable bowel syndrome controls

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In terms of IBS symptom subtypes, IBS-C was the most frequent subtype among IBS patients (49.3%). There were no statistically significant differences between all symptom subgroups in terms of age, sex, race, and psychometric tests (P>0.05) ([Table 4]).
Table 4: Irritable bowel syndrome subtypes

Click here to view



  Discussion Top


The present study showed that the prevalence of IBS among attendants of internal medicine and gastroenterology clinics at Islamic University, Al- Medina Almounawarrha (KSA) was 18.25%, which is considered a moderate prevalence of IBS. A recent meta-analysis showed the lowest occurrence in South Asia (7%) and the highest occurrence in South America (21%) (Lovell and Ford, 2012). Such differences may be attributed to the type of target population, ethnic variations between target populations, and work load.

Our findings showed that women had a higher prevalence; the difference was statistically significant. This is similar to the results of many studies (Hungin et al., 2003; Abdulmajeed et al., 2011; Okami et al., 2011). Results of a systematic review from Iran (Jahangiri et al., 2012), showed that more than half of the reviewed studies reported that the prevalence of IBS had statistically a significant correlation with female sex.

Our results found that age, nationality, and living condition were not associated with IBS, which is in agreement with the results of the study in Jeddah (Ibrahim et al., 2013).

There was an association between poor physical exercise and IBS in the current study. The results from a recent systematic review of 16 studies carried out among medical students showed that some studies found protective effects of physical activities, whereas other studies did not find such an association (Ibrahim, 2016).

The current results do not show any association between smoking and IBS. This is in line with the results of Chirila et al. (2012) from Romania. Similarly, our study showed that there is no significant association between IBS and caffeine.

Our findings indicated the presence of a statistical association between the prevalence of IBS and food hypersensitivity. This result is in agreement with the results from Jeddah (Ibrahim et al., 2013), and many studies in a systematic review (Ibrahim, 2016), and with results from Italy (Carroccio et al., 2011). In the current study, the majority of IBS patients (82.2%) had a family history of IBS with a statistically significant difference. This is similar to the findings of Saito et al. (2010) from the USA and the results of many studies on medical students described in a systematic review (Ibrahim, 2016). Similarly, another review published in 2016 reported the presence of an inherited component in IBS, which was confirmed in twin and family studies (Henstrom and D’Amato, 2016).

Studies have reported that IBS is associated with emotional and psychological stress (Savas et al., 2009; Naeem et al., 2012). In the present study, emotional stress was evident in 65.8% of IBS patients. Al-Turki et al. (2011) found that the presence of psychological stress was much higher among students who had IBS in King Saud University, Riyadh, Saudi Arabia. Psychosocial stress and psychopathology are increased in functional disorders, but not in all individuals, and is generally considered to be a cause rather than the consequence of functional disorders (Barsky and Borus, 1999).

In the current study, 54.8% of IBS patients had a history of traveler’s diarrhea with a statistically significant difference. Recent studies have suggested that patients who experience an episode of infectious diarrhea may develop new IBS at a relatively high rate (Park et al., 2005).

Poor sleep quality in the current study was present in 56.2% of IBS patients compared with non-IBS patients, with a statistically significant difference. Poor sleep may be a hazardous stress issue that can influence gastrointestinal function, cognition, emotion, and somatic reaction. It may disrupt the biological rhythm and hence alter gut motility (Ibrahim, 2016). This is in agreement with the results of many other studies (Ibrahim et al., 2013; Ibrahim, 2016). Similarly, another study carried out among healthy nurses in Singapore founded that poor sleep quality could affect bowel functions even in healthy individuals (Gwee, 2011).

Studies with an adequate number of patients and a standardized psychiatric interview indicated that 50–60% of IBS patients in gastroenterology clinics have psychiatric disorders. The proportion is similar to patients entering treatment trials for IBS symptoms (Carroccio et al., 2011). In this study, the prevalence of anxiety–depressive disorders in IBS patients was 63%: depression was present in 24.6%, anxiety was present in 22%, and comorbid depression–anxiety disorder was present in 16.4%, with no statistically significant difference. American studies have found that anxiety disorders were highly prevalent in IBS outpatients (39.7–52.4%) (Blanchard et al., 2001). This discrepancy may be related to the research methodology, study population, measuring tools, sampling, and sample sizes, which may influence the outputs of surveys. The high prevalence of anxiety and depression in the local general population (20.8 and 21%, respectively) (Noorbala et al., 2004) must be considered an important factor in the higher prevalence of these diseases in the IBS patients studied. IBS patients with anxiety disorder or depression had more severe symptoms and poor health outcomes (Thijssen et al., 2010).


  Conclusion Top


This study found a high prevalence (18.25%) of IBS among attendants of internal medicine and gastroenterology clinics in Islamic University in Al-Medina, KSA. Female sex, family history of IBS, presence of emotional stress, traveler’s diarrhea, and poor sleep quality were evident in IBS patients. Because of the high prevalence of anxiety–depressive disorders among IBS patients, psychiatric assessments should be performed as an important part of the management plan for IBS patients.

Recommendations

Psychological assessment should be recommended in patients with functional bowel disorders. The screening of patients for anxiety and depression can be performed easily through a patient questionnaire and this is the basis of and justification for additional therapeutic interventions, which have been shown to be effective in improving gastrointestinal symptom severity and quality of life of IBS patients. [43]

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

 
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Abstract
Introduction
Aim of the study
Patients and methods
Results
Discussion
Conclusion
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