• Users Online: 79
  • Home
  • Print this page
  • Email this page
Home Current issue Archives Ahead of print Search Subscribe Instructions Submit article About us Editorial board Contacts Login 
Year : 2019  |  Volume : 40  |  Issue : 2  |  Page : 86-94

Effect of zinc supplementation in zinc-deficient children with attention-deficit hyperactivity disorder

1 Department of Psychiatry, Faculty of Medicine, Cairo University, Cairo, Egypt
2 Department of Occupational and Environmental Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt

Correspondence Address:
Dina Y Afifi
Department of Psychiatry, Faculty of Medicine, Cairo University, Cairo, 11562
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ejpsy.ejpsy_10_19

Rights and Permissions

Background Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder increasing in prevalence. Although there is limited evidence to support treating ADHD with mineral supplements, research does exist showing that patients with ADHD may have reduced levels of zinc, ferritin, and magnesium. These nutrients have important roles in neurologic function, including involvement in neurotransmitter synthesis. In spite of the good response of many patients with ADHD to stimulant drugs, a substantial percent do not respond to or develop significant side effects from stimulants. For this reason, zinc treatment has been considered to show positive results on various symptoms in ADHD patients with zinc deficiency. Objectives The aim of this study is to elucidate the effect of zinc supplementation on ADHD symptoms in zinc-deficient ADHD children. Patients and methods Thirty zinc-deficient children diagnosed with ADHD and on a fixed dose of methylphenidate were enrolled in this study. They were assigned to zinc supplementation (30 mg/day) as gluconate in an open-label follow-up trial for 10 weeks. Results There was a statistically significant difference among zinc-deficient ADHD children before and after zinc supplementation on all working memory index subtest scores and all Conner’s subscale scores. This result points to the effect of zinc supplementation on ADHD symptom domains.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded258    
    Comments [Add]    
    Cited by others 2    

Recommend this journal