Association of angiotensin-converting enzyme gene polymorphism and clinical characteristics in Egyptian patients with major depressive disorder
Adel ElMissiry1, Fatma A Abuzahra2, Marwa ElMissiry3, Eman Shorub3, Reem Hashim3, Dalia A.M Mahmoud3
1 Department of Micobiology & Molecular Biology, Okasha Institute of Psychiatry, Faculty of Medicine, Ain Shams University Hospitals, Cairo, Egypt 2 Tissue Culture Lab, Medical Research Center (MRC), Okasha Institute of Psychiatry, Faculty of Medicine, Ain Shams University Hospitals, Cairo, Egypt 3 Department of Psychiatry, Okasha Institute of Psychiatry, Faculty of Medicine, Ain Shams University Hospitals, Cairo, Egypt
Correspondence Address:
MD Dalia A.M Mahmoud Department of Psychiatry, Okasha Institute of Psychiatry, Faculty of Medicine, Ain Shams University Hospitals, 38 Abbasia, Nour Mosque, El-Mohamady, Al Waili, Cairo Governorate, 11657 Egypt
Source of Support: None, Conflict of Interest: None | Check |
DOI: 10.4103/ejpsy.ejpsy_49_20
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Objectives Depression is one of the leading causes of disability and suicide worldwide. It has strong genetic etiopathogenesis, especially that related to angiotensin-converting enzyme (ACE) gene polymorphism. Therefore, this research tackled the relation between genetic variants of ACE polymorphism and symptomatology profile of major depression.
Patients and methods A total of 42 patients diagnosed with depression matched with 39 controls underwent Structured Clinical Interview for the DSM-IV Axis I diagnosis clinician version, Structured Clinical Interview for the DSM-IV Axis I diagnosis-nonpatient edition, Hamilton Depression Rating Scale, real-time PCR for genotyping, and serum cortisol level assay.
Results ACE I/D gene polymorphism was significantly higher in patients with major depression (45.2%) compared with the control group (25.6%). Patients with I/D polymorphism showed longer duration of illness; greater severity; higher number of episodes and rate of hospitalization; higher tendency to be prescribed serotonin/norepinephrine reuptake inhibitors and to receive electroconvulsive therapy; higher scores of core depressive symptoms, such as guilt feeling, inability to work, and suicidal ideation; and higher serum cortisol level than the other genotype groups.
Conclusion Our findings support the notion that ACE I/D polymorphism affects major depression severity and symptomatology imprint.
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