|LETTER TO THE EDITOR
|Year : 2022 | Volume
| Issue : 1 | Page : 59-61
Later life depression as a risk factor for developing dementia: how much influence does the post-pandemic era have?
Lina S Arce1, Andres F Ardila2, Diana C Caicedo-Posso3, Kelly N Molina-Perea1, Ivan D Lozada-Martinez4
1 School of Medicine, Universidad Juan N Corpas, Bogotá, Colombia
2 School of Medicine, Universidad Autónoma de Bucaramanga, Bucaramanga, Colombia
3 School of Medicine, Universidad Icesi, Cali, Colombia
4 Medical and Surgical Research Center, University of Cartagena, Cartagena; Global Neurosurgery Committee, World Federation of Neurosurgical Societies, Colombian Chapter, Cartagena, Colombia
|Date of Submission||19-Jul-2021|
|Date of Decision||27-Aug-2021|
|Date of Acceptance||30-Aug-2021|
|Date of Web Publication||26-Feb-2022|
MS Ivan D Lozada-Martinez
Medical and Surgical Research Center, University of Cartagena, Cartagena 130004
Source of Support: None, Conflict of Interest: None
By the year 2050, it is estimated that at least 20% of the world’s population will be over the age of 65. Depression in late life is a serious public health problem that has a negative and substantial impact on the quality of life of older adults, their families, and their social circle. Depression, in turn, constitutes a risk and prognostic factor for the development or worsening of dementia, a condition present in about 10% of the population over 60 years of age, and which increases and intensifies with age, being up to 40% at age 90. In the context of the current COVID-19 pandemic, aspects such as persistent isolation and loneliness, socioeconomic distress, lack of family and professional support, fear of illness and death, are potential negative risk factors for developing depression and worsening the prognosis of dementia in older adults.
Keywords: aged, dementia, dementia, depression, pandemic, risk factors
|How to cite this article:|
Arce LS, Ardila AF, Caicedo-Posso DC, Molina-Perea KN, Lozada-Martinez ID. Later life depression as a risk factor for developing dementia: how much influence does the post-pandemic era have?. Egypt J Psychiatr 2022;43:59-61
|How to cite this URL:|
Arce LS, Ardila AF, Caicedo-Posso DC, Molina-Perea KN, Lozada-Martinez ID. Later life depression as a risk factor for developing dementia: how much influence does the post-pandemic era have?. Egypt J Psychiatr [serial online] 2022 [cited 2022 Jul 7];43:59-61. Available from: http://new.ejpsy.eg.net/text.asp?2022/43/1/59/338560
The rapid increase in the number of older adults around the world makes the management of mental disorders and associated complications in this age group a challenge. By the year 2050, it is estimated that at least 20% of the world’s population will be over the age of 65 (Aziz and Steffens, 2013). Depression in late life is a serious public health problem that has a negative and substantial impact on the quality of life of older adults, their families, and their social circle (Ding and Kennedy, 2021). The prevalence of this condition is estimated to be 17% (McCombe et al., 2018), which is closely related to suicide rates of 20% among all suicide deaths at all ages (National Institute of Mental Health, 2019). This condition carries high health costs in specialized care, medication, rehabilitation, and decompensation of previous comorbidities (Aziz and Steffens, 2013; Ding and Kennedy, 2021).
Countless risk factors have been described for the development of depression in the elderly, biological factors (mutations or genetic polymorphism, cerebrovascular disease, and coronary heart disease, among others), psychological factors (loneliness, low social support, low education, and poor nutritional status, among others), and social factors (low socioeconomic status, difficulty in accessing health services, and stressful situations, among others) (Aziz and Steffens, 2013). These factors influence neuronal dynamics, reducing the secretion of neurotropic factors and decreasing neurogenesis. In turn, neuroinflammatory signaling pathways are activated with alteration of neuroendocrine processes that do not allow the proper functioning of neurotransmitters and hinder the performance of activities of daily living, intensifying the impact of other risk factors such as cardiovascular (whose control depends on adherence to pharmacological treatment), psychological (behavior and social interaction), and social (response to stressful situations), turning this condition into a vicious circle (Fiske et al., 2009). Considering also that neuroplasticity in the elderly is limited due to the presence of fragility and physiological oxidation, recovery from this pathological entity is more complex.
Depression, in turn, constitutes a risk and prognostic factor for the development or worsening of dementia (Wang et al., 2021), a condition present in about 10% of the population over 60 years of age, and which increases and intensifies with age, being up to 40% at age 90 (World Health Organization, 2020). Currently, under the ravages of the coronavirus disease 2019 (COVID-19) pandemic, all aspects of human life have been affected (Aisenberg-Shafran et al., 2021). Older adults are the population most at risk of developing the severe COVID-19 phenotype and dying, so restriction measures are more severe in them. Persistent isolation and loneliness, barriers to family support, declining socioeconomic status, difficulty of participating in recreational events, the receipt of negative news through the social media, and fear of illness and death are potential risk factors for anxiety and depression in this population at this time (Aziz and Steffens, 2013; Aisenberg-Shafran et al., 2021; Ding and Kennedy, 2021; Wang et al., 2021); thus, also factors to worsen the prognosis of dementia in those who already suffer from it, and in addition, have other pathological conditions that affect neurological integrity, such as silent neurovascular disease. The pathophysiological mechanism of depression in COVID-19, would be mainly related to psychological and social factors (described previously), and the acceleration in dementia due to altered control of chronic noncommunicable diseases with impact on the central nervous system, neuroinflammation due to SARS-Cov-2 infection, and the inability to stimulate neuronal activity due to confinement, constant fear, lack of social interaction, and coping with the death of loved ones and/or acquaintances (Bueno-Notivol et al., 2021). This is consistent with the high overall prevalence of depression during the pandemic found in meta-analyses [25%; 95% confidence interval (CI): 18−33%] (Bueno-Notivol et al., 2021). The hardest part of all this is that there is a bidirectional relationship between depression and dementia. Studies have found that patients with higher cognitive function are less likely to develop depression; however, depression as a pathological condition that inhibits cognitive functions adversely modifies the prognosis of those with dementia, thus intensifying the degree and persistence of depression, confirming the presence of a vicious cycle (Gale et al., 2012).In this order of ideas, and under the modification of lifestyle in the post-pandemic era, it is valid to ask what is and will be the prognosis of depression and dementia in the coming years in this population? Even more so, when there are emerging conditions such as post-COVID-19 neurological syndrome, which results from neuroinflammation during the acute phase of COVID-19, with the potential to generate or modify the prognosis of neuropsychiatric diseases as well (Camargo-Martínez et al., 2021). Wang et al. (2021) conducted a longitudinal study evaluating the effect of late-life depression and cognitive decline on dementia (Wang et al., 2021). The authors found that presenting with depressive symptoms (aHR: 1.286; 95% CI, 1.255–1.318), having recently had depression (aHR: 1.697; 95% CI, 1.621–1.776), and presenting with subjective cognitive decline (aHR: 1.748; 95% CI, 689–1.808) substantially increased the risk of dementia, and presenting with depression and cognitive decline even more (aHR: 2.466; 95% CI, 689–1.808. 748; 95% CI, 689–1.808) (Wang et al., 2021). However, Yu and Mahendran (2021) recently published a study where they showed that COVID-19 pandemic confinement negatively influenced the dynamics of affective symptoms and isolation, where symptoms of depression and anxiety were very intense and increased the risk of various affective disorders (Yu and Mahendran, 2021).
Therefore, it is necessary to modify the management and risk stratification of these patients, considering that there is a high risk of depression and possible risk of self-harm and suicide, as well as genesis of dementia and worsening of the prognosis of these patients, so it is necessary to implement strategies aimed at strict monitoring, social and family support, and comprehensive mental health care. An interesting proposal would be the implementation of post-COVID-19 centers, aimed at identifying and determining the degree of psychological and neuropsychiatric involvement of the entire population, in order to estimate with greater certainty, the overall prevalence of this type of disorders in all age groups, and to establish a personalized management.
Funding: The research was totally funded by the researchers.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Aisenberg-Shafran D, Bar-Tur L, Levi-Belz Y (2021). Who is really at risk? The contribution of death anxiety in suicide risk and loneliness among older adults during the COVID-19 pandemic. Death Stud 19:1–6.
Aziz R, Steffens DC (2013). What are the causes of late-life depression? Psychiatr Clin North Am 36:497–516.
Bueno-Notivol J, Gracia-García P, Olaya B, Lasheras I, López-Antón R, Santabárbara J (2021). Prevalence of depression during the COVID-19 outbreak: a meta-analysis of community-based studies. Int J Clin Health Psychol 21:100196.
Camargo-Martínez W, Lozada-Martínez I, Escobar-Collazos A, Navarro-Coronado A, Moscote-Salazar L et al.
(2021). Post-COVID 19 neurological syndrome: implications for sequelae’s treatment. J Clin Neurosci 88:219–225.
Ding OJ, Kennedy GJ (2021). Understanding vulnerability to late-life suicide. Curr Psychiatry Rep 23:58.
Fiske A, Wetherell JL, Gatz M (2009). Depression in older adults. Annu Rev Clin Psychol 5:363–389.
Gale CR, Allerhand M, Deary IJ, HALCyon Study Team (2012) Is there a bidirectional relationship between depressive symptoms and cognitive ability in older people? A prospective study using the English longitudinal study of ageing. Psychol Med 42:2057–2069.
McCombe G, Fogarty F, Swan D, Hannigan A, Fealy GM, Kyne L et al.
(2018) Identified mental disorders in older adults in primary care: a cross-sectional database study. Eur J Gen Pract 24:84–91.
Wang SM, Han KD, Kim NY, Um YH, Kang DW, Na HR et al.
(2021) Late-life depression, subjective cognitive decline, and their additive risk in incidence of dementia: a nationwide longitudinal study. PLoS ONE 16:e0254639.
Yu J, Mahendran R (2021) COVID-19 lockdown has altered the dynamics between affective symptoms and social isolation among older adults: results from a longitudinal network analysis. Sci Rep 11:14739.