%A Tantawy, Ashraf %A Al-Yahia, Abduhamid %A Raya, Yasser %A Al-Mohaimeed, Abdurrahman %A Settin, Ahmad %T Catechol-O-methyltransferase gene polymorphisms in Saudi cases with schizophrenia %9 Original Article %D 2015 %J Egyptian Journal of Psychiatry %P 118-123 %V 36 %N 3 %U https://new.ejpsy.eg.net//article.asp?issn=1110-1105;year=2015;volume=36;issue=3;spage=118;epage=123;aulast=Tantawy %8 September 1, 2015 %X Background This work was conducted to test for the association of genetic polymorphisms of catechol-O-methyltransferase (COMT) with the susceptibility and clinical patterns of schizophrenia among Saudi patients. Participants and methods This is a case-control study involving 79 patients fulfilling the ICD-10 criteria of schizophrenia and 82 healthy controls. Patients were interviewed by different tools, which included the Diagnostic Interview for Genetic Studies (DIGS/V4.0), the Positive and Negative Symptoms Scale (PANSS), and the World Health Organization Disability Assessment Schedule (version 2.0) (WHO/DAS II). All patients and controls were screened for COMT G >A gene polymorphisms using the real-time PCR technique. Results Frequencies of all genetic variants of COMT G >A [V158M] did not show a significant difference on comparing cases with controls (P > 0.05). Comparing the frequencies of genetic variants in cases having positive parental consanguinity and a family history of schizophrenia or other mental illnesses with those without a history also showed nonsignificant results (P > 0.05). A stratified analysis related to severity scores and associated clinical illnesses also showed a nonsignificant difference (P > 0.05). Conclusion Polymorphism related to COMT G >A was not associated with the susceptibility and the severity of schizophrenia among Saudi cases. %0 Journal Article %I Wolters Kluwer Medknow Publications %@ 1110-1105