Egyptian Journal of Psychiatry

ORIGINAL ARTICLE
Year
: 2012  |  Volume : 33  |  Issue : 2  |  Page : 83--89

Homocysteine level and depression in patients with ischaemic heart disease


Mohamed Nashaat1, Emad Hamdi1, Shereen Mohamed Abdel Mawella1, Dalal Amer1, Aref Khoweiled1, Hoda Abdou1, Amal Abdou2 
1 Department of Psychiatry, Faculty of Medicine, Cairo University, Giza, Egypt
2 Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Giza, Egypt

Correspondence Address:
Shereen Mohamed Abdel Mawella
Department of Psychiatry, Faculty of Medicine, Cairo University, Giza
Egypt

Background

High levels of homocysteine are associated with vascular disease, changes in the levels of monoamine neurotransmitters and depression. A plausible hypothesis for these associations is that high homocysteine levels are implicated in vascular disease and neurotransmitter deficiency, which are in turn linked to depression.

Aim

To investigate the association between elevated homocysteine levels and depressive symptoms in patients with ischaemic heart disease (IHD).

Participants and methods

Eighty patients with a confirmed diagnosis of IHD were consecutively selected in a cross-sectional study from the inpatient and outpatient cardiology department of Kasr-Al-Ainy hospital. All IHD patients were diagnosed according to the criteria of the American College of Cardiology. Depression was evaluated using the Present State Examination-10 Short English–Arabic Version and the Beck Depressive Inventory. The serum level of homocysteine was determined using the chemiluminescent technique.

Results

Thirty-six ischaemic heart patients (45%) had depressive disorders. Depressed patients were older and had a longer duration of the IHD. The level of homocysteine was higher in depressed patients (P=0.098). Positive correlations were found between age and the serum level of homocysteine (P=0.028) but no correlations were found between the serum level of homocysteine and the severity of depression. Sleep disturbances correlated significantly with homocysteine levels irrespective of age.

Conclusion

Depressive symptoms are common in IHD patients, especially patients with prolonged duration of the disease. They are more apparent in IHD patients at times of emergency and intervention. In IHD patients, the serum level of homocysteine is associated with the occurrence of vegetative depressive symptoms.




How to cite this article:
Nashaat M, Hamdi E, Mawella SA, Amer D, Khoweiled A, Abdou H, Abdou A. Homocysteine level and depression in patients with ischaemic heart disease.Egypt J Psychiatr 2012;33:83-89


How to cite this URL:
Nashaat M, Hamdi E, Mawella SA, Amer D, Khoweiled A, Abdou H, Abdou A. Homocysteine level and depression in patients with ischaemic heart disease. Egypt J Psychiatr [serial online] 2012 [cited 2022 Nov 30 ];33:83-89
Available from: https://new.ejpsy.eg.net//article.asp?issn=1110-1105;year=2012;volume=33;issue=2;spage=83;epage=89;aulast=Nashaat;type=0