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Figure 1 Photomicrograph of brain sections of rats from the control and experimental groups. (a) Normal control. (b) The galantamine (Gal)-treated group showing no alterations from controls. (c, d) Alzheimer’s disease-induced rats showing amyloid plaques of different sizes, perivascular edema, and diffused gliosis. (e) Alzheimer’s disease-induced rats after Gal therapy showing persistence of amyloid plagues and diffused gliosis. (f, g) Alzheimer’s disease-induced rats treated with Gal coated with cerium/calcium hydroxyapatite showing near-to-normal patterns in the cerebral cortex and hippocampus. (h) Alzheimer’s disease-induced rats treated with Gal coated with carboxymethyl chitosan/ceria/calcium hydroxyapatite showing persistence of lesions. Hematoxylin and eosin, ´200. cc, the cerebral cortex; hp, hippocampus; p, amyloid plaques. |
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